Phosphinate esters as novel warheads for activity-based probes targeting serine proteases

Activity-based protein profiling enables the specific detection of the active fraction of an enzyme and is of particular use for the profiling of proteases. The technique relies on a mechanism-based reaction between small molecule activity-based probes (ABPs) with the active enzyme. Here we report a...

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Detalles Bibliográficos
Autores principales: Kahler, Jan Pascal, Verhelst, Steven H. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341442/
https://www.ncbi.nlm.nih.gov/pubmed/34458842
http://dx.doi.org/10.1039/d1cb00117e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341442/
https://www.ncbi.nlm.nih.gov/pubmed/34458842
http://dx.doi.org/10.1039/d1cb00117e

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