A peptidic inhibitor for PD-1 palmitoylation targets its expression and functions

Programmed cell death protein 1 (PD-1) is a crucial anticancer target, but the relatively low response rate and acquired resistance to existing antibody drugs highlight an urgent need to develop alternative targeting strategies. Here, we report the palmitoylation of PD-1, discover the main DHHC enzy...

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Detalles Bibliográficos
Autores principales: Yao, Han, Li, Chushu, He, Fang, Song, Teng, Brosseau, Jean-Philippe, Wang, Huanbin, Lu, Haojie, Fang, Caiyun, Shi, Hubing, Lan, Jiang, Fang, Jing-Yuan, Xu, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341464/
https://www.ncbi.nlm.nih.gov/pubmed/34458782
http://dx.doi.org/10.1039/d0cb00157k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341464/
https://www.ncbi.nlm.nih.gov/pubmed/34458782
http://dx.doi.org/10.1039/d0cb00157k

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