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Revision in the first steps of the biosynthesis of the red antibiotic prodigiosin: use of a synthetic thioester to validate a new intermediate

A biosynthetic pathway for the red-antibiotic, prodigiosin, was proposed over a decade ago but not all the suggested intermediates could be detected experimentally. Here we show that a thioester that was not originally included in the pathway is an intermediate. In addition, the enzyme PigE was orig...

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Detalles Bibliográficos
Autores principales: Couturier, Maxime, Bhalara, Hiral D., Monson, Rita E., Salmond, George P. C., Leeper, Finian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341465/
https://www.ncbi.nlm.nih.gov/pubmed/34458798
http://dx.doi.org/10.1039/d0cb00173b