Shared genomic segment analysis in a large high-risk chronic lymphocytic leukemia pedigree implicates CXCR4 in inherited risk

AIM: Chronic lymphocytic leukemia (CLL) has been shown to cluster in families. First-degree relatives of individuals with CLL have an ~8 fold increased risk of developing the malignancy. Strong heritability suggests pedigree studies will have good power to localize pathogenic genes. However, CLL is...

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Detalles Bibliográficos
Autores principales: Feusier, Julie E., Madsen, Michael J., Avery, Brian J., Williams, Justin A., Stephens, Deborah M., Hu, Boyu, Osman, Afaf E. G., Glenn, Martha J., Camp, Nicola J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341589/
https://www.ncbi.nlm.nih.gov/pubmed/34368645
http://dx.doi.org/10.20517/jtgg.2021.05

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341589/
https://www.ncbi.nlm.nih.gov/pubmed/34368645
http://dx.doi.org/10.20517/jtgg.2021.05

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