Mitochondria-targeted inhibitors of the human SIRT3 lysine deacetylase

Sirtuin 3 (SIRT3) is the major protein lysine deacetylase in the mitochondria. This hydrolase regulates a wide range of metabolically involved enzymes and has been considered as a potential drug target in certain cancers. Investigation of pharmacological intervention has been challenging due to a la...

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Detalles Bibliográficos
Autores principales: Troelsen, Kathrin S., Bæk, Michael, Nielsen, Alexander L., Madsen, Andreas S., Rajabi, Nima, Olsen, Christian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341665/
https://www.ncbi.nlm.nih.gov/pubmed/34458804
http://dx.doi.org/10.1039/d0cb00216j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341665/
https://www.ncbi.nlm.nih.gov/pubmed/34458804
http://dx.doi.org/10.1039/d0cb00216j

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