Sub-stoichiometric inhibition of IAPP aggregation: a peptidomimetic approach to anti-amyloid agents

Membrane-catalysed misfolding of islet amyloid polypeptide is associated with the death of β-cells in type II diabetes (T2D). Most active compounds so far reported require high doses for inhibition of membrane bound IAPP fibrillation. Here, we describe a naphthalimide-appended oligopyridylamide-base...

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Detalles Bibliográficos
Autores principales: Maity, Debabrata, Kumar, Sunil, AlHussein, Ruyof, Gremer, Lothar, Howarth, Madeline, Karpauskaite, Laura, Hoyer, Wolfgang, Magzoub, Mazin, Hamilton, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341728/
https://www.ncbi.nlm.nih.gov/pubmed/34458762
http://dx.doi.org/10.1039/d0cb00086h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341728/
https://www.ncbi.nlm.nih.gov/pubmed/34458762
http://dx.doi.org/10.1039/d0cb00086h

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