Combined computational and intracellular peptide library screening: towards a potent and selective Fra1 inhibitor

To date, most research into the inhibition of oncogenic transcriptional regulator, Activator Protein 1 (AP-1), has focused on heterodimers of cJun and cFos. However, the Fra1 homologue remains an important cancer target. Here we describe library design coupled with computational and intracellular sc...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Miao, Ghamsari, Lila, Rotolo, Jim A., Kappel, Barry J., Mason, Jody M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341738/
https://www.ncbi.nlm.nih.gov/pubmed/34458807
http://dx.doi.org/10.1039/d1cb00012h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341738/
https://www.ncbi.nlm.nih.gov/pubmed/34458807
http://dx.doi.org/10.1039/d1cb00012h

Ejemplares similares