In silico peptide-directed ligand design complements experimental peptide-directed binding for protein–protein interaction modulator discovery

Using the protein–protein interaction of Mcl-1/Noxa, two methods for efficient modulator discovery are directly compared. In silico peptide-directed ligand design is evaluated against experimental peptide-directed binding, allowing for the discovery of two new inhibitors of Mcl-1/Noxa with cellular...

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Detalles Bibliográficos
Autores principales: Howell, Lesley Ann, Beekman, Andrew Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341744/
https://www.ncbi.nlm.nih.gov/pubmed/34458784
http://dx.doi.org/10.1039/d0cb00148a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341744/
https://www.ncbi.nlm.nih.gov/pubmed/34458784
http://dx.doi.org/10.1039/d0cb00148a

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