Cargando…
In silico peptide-directed ligand design complements experimental peptide-directed binding for protein–protein interaction modulator discovery
Using the protein–protein interaction of Mcl-1/Noxa, two methods for efficient modulator discovery are directly compared. In silico peptide-directed ligand design is evaluated against experimental peptide-directed binding, allowing for the discovery of two new inhibitors of Mcl-1/Noxa with cellular...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
RSC
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341744/ https://www.ncbi.nlm.nih.gov/pubmed/34458784 http://dx.doi.org/10.1039/d0cb00148a |