Tau oligomer induced HMGB1 release contributes to cellular senescence and neuropathology linked to Alzheimer’s disease and frontotemporal dementia

Aging, pathological tau oligomers (TauO), and chronic inflammation in the brain play a central role in tauopathies, including Alzheimer’s disease (AD) and frontotemporal dementia (FTD). However, the underlying mechanism of TauO-induced aging-related neuroinflammation remains unclear. Here, we show t...

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Detalles Bibliográficos
Autores principales: Gaikwad, Sagar, Puangmalai, Nicha, Bittar, Alice, Montalbano, Mauro, Garcia, Stephanie, McAllen, Salome, Bhatt, Nemil, Sonawane, Minal, Sengupta, Urmi, Kayed, Rakez
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341760/
https://www.ncbi.nlm.nih.gov/pubmed/34289368
http://dx.doi.org/10.1016/j.celrep.2021.109419

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341760/
https://www.ncbi.nlm.nih.gov/pubmed/34289368
http://dx.doi.org/10.1016/j.celrep.2021.109419

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