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Optogenetic modulation of real-time nanoscale dynamics of HCN channels using photoactivated adenylyl cyclases

Adenosine 3′,5′-cyclic monophosphate (cAMP) is a key second messenger that activates several signal transduction pathways in eukaryotic cells. Alteration of basal levels of cAMP is known to activate protein kinases, regulate phosphodiesterases and modulate the activity of ion channels such as Hyper...

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Detalles Bibliográficos
Autores principales: Tanwar, Meenakshi, Kateriya, Suneel, Nair, Deepak, Jose, Mini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341789/
https://www.ncbi.nlm.nih.gov/pubmed/34458814
http://dx.doi.org/10.1039/d0cb00124d