Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping

Monoamine oxidases MAOA and MAOB catalyze important cellular functions such as the deamination of neurotransmitters. Correspondingly, MAO inhibitors are used for the treatment of severe neuropsychiatric disorders such as depression. A commonly prescribed drug against refractory depression is tranylc...

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Detalles Bibliográficos
Autores principales: Drechsel, Jonas, Kyrousi, Christina, Cappello, Silvia, Sieber, Stephan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341850/
https://www.ncbi.nlm.nih.gov/pubmed/34458760
http://dx.doi.org/10.1039/d0cb00048e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341850/
https://www.ncbi.nlm.nih.gov/pubmed/34458760
http://dx.doi.org/10.1039/d0cb00048e

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