Structural and biophysical insights into the mode of covalent binding of rationally designed potent BMX inhibitors

The bone marrow tyrosine kinase in chromosome X (BMX) is pursued as a drug target because of its role in various pathophysiological processes. We designed BMX covalent inhibitors with single-digit nanomolar potency with unexploited topological pharmacophore patterns. Importantly, we reveal the first...

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Detalles Bibliográficos
Autores principales: Seixas, João D., Sousa, Bárbara B., Marques, Marta C., Guerreiro, Ana, Traquete, Rui, Rodrigues, Tiago, Albuquerque, Inês S., Sousa, Marcos F. Q., Lemos, Ana R., Sousa, Pedro M. F., Bandeiras, Tiago M., Wu, Di, Doyle, Shelby K., Robinson, Carol V., Koehler, Angela N., Corzana, Francisco, Matias, Pedro M., Bernardes, Gonçalo J. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341910/
https://www.ncbi.nlm.nih.gov/pubmed/34458764
http://dx.doi.org/10.1039/d0cb00033g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341910/
https://www.ncbi.nlm.nih.gov/pubmed/34458764
http://dx.doi.org/10.1039/d0cb00033g

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