Direct targeting of TDP-43, from small molecules to biologics: the therapeutic landscape

Tar DNA binding (TDP)-43 proteinopathy, typically described as cytoplasmic accumulation of highly modified and misfolded TDP-43 molecules, is characteristic of several neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS) and limbic-predominant age-related TDP-43 encephalopathy (LAT...

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Detalles Bibliográficos
Autores principales: Francois-Moutal, Liberty, Scott, David Donald, Khanna, May
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341936/
https://www.ncbi.nlm.nih.gov/pubmed/34458829
http://dx.doi.org/10.1039/d1cb00110h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341936/
https://www.ncbi.nlm.nih.gov/pubmed/34458829
http://dx.doi.org/10.1039/d1cb00110h

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