Finding and characterizing a catalytic antibody light chain, H34, capable of degrading the PD-1 molecule

Programmed cell death 1 (PD-1) is an immune checkpoint molecule regulating T-cell function. Preventing PD-1 binding to its ligand PD-L1 has emerged as an important tool in immunotherapy. Here, we describe a unique human catalytic antibody light chain, H34, which mediates enzymatic degradation of hum...

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Detalles Bibliográficos
Autores principales: Hifumi, Emi, Taguchi, Hiroaki, Nonaka, Tamami, Harada, Takunori, Uda, Taizo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341958/
https://www.ncbi.nlm.nih.gov/pubmed/34458785
http://dx.doi.org/10.1039/d0cb00155d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341958/
https://www.ncbi.nlm.nih.gov/pubmed/34458785
http://dx.doi.org/10.1039/d0cb00155d

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