Quantitative live-cell imaging and computational modeling shed new light on endogenous WNT/CTNNB1 signaling dynamics

WNT/CTNNB1 signaling regulates tissue development and homeostasis in all multicellular animals, but the underlying molecular mechanism remains incompletely understood. Specifically, quantitative insight into endogenous protein behavior is missing. Here, we combine CRISPR/Cas9-mediated genome editing...

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Detalles Bibliográficos
Autores principales: de Man, Saskia MA, Zwanenburg, Gooitzen, van der Wal, Tanne, Hink, Mark A, van Amerongen, Renée
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341982/
https://www.ncbi.nlm.nih.gov/pubmed/34190040
http://dx.doi.org/10.7554/eLife.66440

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341982/
https://www.ncbi.nlm.nih.gov/pubmed/34190040
http://dx.doi.org/10.7554/eLife.66440

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