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Quantitative live-cell imaging and computational modeling shed new light on endogenous WNT/CTNNB1 signaling dynamics
WNT/CTNNB1 signaling regulates tissue development and homeostasis in all multicellular animals, but the underlying molecular mechanism remains incompletely understood. Specifically, quantitative insight into endogenous protein behavior is missing. Here, we combine CRISPR/Cas9-mediated genome editing...
Autores principales: | de Man, Saskia MA, Zwanenburg, Gooitzen, van der Wal, Tanne, Hink, Mark A, van Amerongen, Renée |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341982/ https://www.ncbi.nlm.nih.gov/pubmed/34190040 http://dx.doi.org/10.7554/eLife.66440 |
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