Untangling the interaction of α-synuclein with DNA i-motifs and hairpins by volume-sensitive single-molecule FRET spectroscopy

The intrinsically disordered protein α-synuclein causes Parkinson's disease by forming toxic oligomeric aggregates inside neurons. Single-molecule FRET experiments revealed conformational changes of noncanonical DNA structures, such as i-motifs and hairpins, in the presence of α-synuclein. Volu...

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Detalles Bibliográficos
Autores principales: Mukherjee, Sanjib K., Knop, Jim-Marcel, Oliva, Rosario, Möbitz, Simone, Winter, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341996/
https://www.ncbi.nlm.nih.gov/pubmed/34458831
http://dx.doi.org/10.1039/d1cb00108f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341996/
https://www.ncbi.nlm.nih.gov/pubmed/34458831
http://dx.doi.org/10.1039/d1cb00108f

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