Intermediary conformations linked to the directionality of the aminoacylation pathway of nonribosomal peptide synthetases

Nonribosomal peptide synthetases (NRPSs) are multifunctional megaenzymes that govern the stepwise biosynthesis of pharmaceutically important peptides. In an ATP-dependent assembly-line mechanism dedicated domains are responsible for each catalytic step. Crystal structures have provided insight into...

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Detalles Bibliográficos
Autores principales: Mayerthaler, Florian, Feldberg, Anna-Lena, Alfermann, Jonas, Sun, Xun, Steinchen, Wieland, Yang, Haw, Mootz, Henning D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341999/
https://www.ncbi.nlm.nih.gov/pubmed/34458813
http://dx.doi.org/10.1039/d0cb00220h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341999/
https://www.ncbi.nlm.nih.gov/pubmed/34458813
http://dx.doi.org/10.1039/d0cb00220h

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