Cargando…

Metformin Increases Protein Phosphatase 2A Activity in Primary Human Skeletal Muscle Cells Derived from Lean Healthy Participants

OBJECTIVE: To investigate if PP2A plays a role in metformin-induced insulin sensitivity improvement in human skeletal muscle cells. Participants. Eight lean insulin-sensitive nondiabetic participants (4 females and 4 males; age: 21.0 ± 1.0 years; BMI: 22.0 ± 0.7 kg/m(2); 2-hour OGTT: 97.0 ± 6.0 mg/d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mestareehi, Aktham, Zhang, Xiangmin, Seyoum, Berhane, Msallaty, Zaher, Mallisho, Abdullah, Burghardt, Kyle Jon, Kowluru, Anjaneyulu, Yi, Zhengping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342103/ https://www.ncbi.nlm.nih.gov/pubmed/34368369 http://dx.doi.org/10.1155/2021/9979234

Ejemplares similares

Effect of Insulin and Pioglitazone on Protein Phosphatase 2A Interaction Partners in Primary Human Skeletal Muscle Cells Derived from Obese Insulin-Resistant Participants
por: Alghanem, Lana, et al.
Publicado: (2022)

Profiling the Skeletal Muscle Proteome in Patients on Atypical Antipsychotics and Mood Stabilizers
por: Burghardt, Kyle J., et al.
Publicado: (2022)

MON-LB116 FGF-21 Is A Reliable Marker Of Insulin Resistance Before The Occurrence Of Glucose Intolerance
por: sawah, ahmed, et al.
Publicado: (2020)

Atypical Antipsychotics and the Human Skeletal Muscle Lipidome
por: Burghardt, Kyle J., et al.
Publicado: (2018)

SAT-559 Patients with Hyperaldosteronism Have Higher Prevalence of Obstructive Sleep Apnea. From the National Inpatient Sample
por: Ahmed, Fatima, et al.
Publicado: (2020)

Quantitative Proteomics Reveals Transforming Growth Factor β Receptor Targeted by Resveratrol and Hesperetin Coformulation in Endothelial Cells
por: Mestareehi, Aktham, et al.
Publicado: (2023)

Increased Interaction With Insulin Receptor Substrate 1, a Novel Abnormality in Insulin Resistance and Type 2 Diabetes
por: Caruso, Michael, et al.
Publicado: (2014)

Plasma Lactate Levels Increase during Hyperinsulinemic Euglycemic Clamp and Oral Glucose Tolerance Test
por: Berhane, Feven, et al.
Publicado: (2015)

Deoxysphingolipids: β-Cell, Beware of These New Kids on the Block
por: Kowluru, Anjaneyulu
Publicado: (2014)

Protein prenylation in glucose-induced insulin secretion from the pancreatic islet β cell: a perspective
por: Kowluru, Anjaneyulu
Publicado: (2008)

Emerging roles for protein histidine phosphorylation in cellular signal transduction: lessons from the islet β-cell
por: Kowluru, Anjaneyulu
Publicado: (2008)

Oxidative Stress in Cytokine-Induced Dysfunction of the Pancreatic Beta Cell: Known Knowns and Known Unknowns
por: Kowluru, Anjaneyulu
Publicado: (2020)

Peripheral Blood Mitochondrial DNA Damage as a Potential Noninvasive Biomarker of Diabetic Retinopathy
por: Mishra, Manish, et al.
Publicado: (2016)

Epigenetics and Regulation of Oxidative Stress in Diabetic Retinopathy
por: Duraisamy, Arul J., et al.
Publicado: (2018)

Metformin Impairs Mitochondrial Function in Skeletal Muscle of Both Lean and Diabetic Rats in a Dose-Dependent Manner
por: Wessels, Bart, et al.
Publicado: (2014)

Tiam1-Rac1 Axis Promotes Activation of p38 MAP Kinase in the Development of Diabetic Retinopathy: Evidence for a Requisite Role for Protein Palmitoylation
por: Veluthakal, Rajakrishnan, et al.
Publicado: (2015)

Epigenetic Modifications in Peripheral Blood as Potential Noninvasive Biomarker of Diabetic Retinopathy
por: Duraisamy, Arul J., et al.
Publicado: (2019)

Insulin-stimulated phosphorylation of protein phosphatase 1 regulatory subunit 12B revealed by HPLC-ESI-MS/MS
por: Pham, Kimberly, et al.
Publicado: (2012)

CARD9 Mediates Pancreatic Islet Beta-Cell Dysfunction Under the Duress of Hyperglycemic Stress
por: Gamage, Suhadinie, et al.
Publicado: (2022)

Hyperglycemic Conditions Promote Rac1-Mediated Serine536 Phosphorylation of p65 Subunit of NFκB (RelA) in Pancreatic Beta Cells
por: Kowluru, Anjaneyulu, et al.
Publicado: (2022)

Regulatory Roles of Histone Deacetylation in Metabolic Stress-Induced Expression of Caspase Recruitment Domain-Containing Protein 9 (CARD9) in Pancreatic β-Cells
por: Hali, Mirabela, et al.
Publicado: (2023)

Increased Phagocyte-Like NADPH Oxidase and ROS Generation in Type 2 Diabetic ZDF Rat and Human Islets: Role of Rac1–JNK1/2 Signaling Pathway in Mitochondrial Dysregulation in the Diabetic Islet
por: Syed, Ismail, et al.
Publicado: (2011)

Metformin increases pressure pain threshold in lean women with polycystic ovary syndrome
por: Kiałka, Marta, et al.
Publicado: (2016)

P-Rex1 Mediates Glucose-Stimulated Rac1 Activation and Insulin Secretion in Pancreatic β-Cells
por: Thamilselvan, Vijayalakshmi, et al.
Publicado: (2020)

Identification of PP1c-PPP1R12A Substrates Using Kinase-Catalyzed Biotinylation to Identify Phosphatase Substrates
por: Dedigama-Arachchige, Pavithra M., et al.
Publicado: (2023)

Protein tyrosine phosphatases in skeletal development and diseases
por: Yang, Huiliang, et al.
Publicado: (2022)

Lean Participative Process Improvement: Outcomes and Obstacles in Trauma Orthopaedics
por: New, Steve, et al.
Publicado: (2016)

The Participative Design of an Endoscopy Facility using Lean 3P
por: Smith, Iain
Publicado: (2016)

Metformin Does Not Inhibit Exercise-Induced Lipolysis in Adipose Tissue in Young Healthy Lean Men
por: Krauzová, Eva, et al.
Publicado: (2018)

Mechanisms and effects of metformin on skeletal muscle disorders
por: Shang, Ren, et al.
Publicado: (2023)

Protein Farnesylation–Dependent Raf/Extracellular Signal–Related Kinase Signaling Links to Cytoskeletal Remodeling to Facilitate Glucose-Induced Insulin Secretion in Pancreatic β-Cells
por: Kowluru, Anjaneyulu, et al.
Publicado: (2010)

Cold acclimation affects immune composition in skeletal muscle of healthy lean subjects
por: van der Lans, Anouk A J J, et al.
Publicado: (2015)

Levetiracetam Treatment Causing False Negative Screening Test in a Woman With Aldosterone Producing Adenoma
por: Sawah, Ahmed, et al.
Publicado: (2021)

Increased efficacy of metformin corresponds to differential metabolic effects in the ovarian tumors from obese versus lean mice
por: Han, Jianjun, et al.
Publicado: (2017)

The Effect of Metformin on Self-Selected Exercise Intensity in Healthy, Lean Males: A Randomized, Crossover, Counterbalanced Trial
por: Pilmark, Nanna Skytt, et al.
Publicado: (2021)

Prolonged fasting-induced metabolic signatures in human skeletal muscle of lean and obese men
por: Bak, Ann Mosegaard, et al.
Publicado: (2018)

Frataxin deficiency lowers lean mass and triggers the integrated stress response in skeletal muscle
por: Vásquez-Trincado, César, et al.
Publicado: (2022)

Complex and lean or lean and complex? The role of supply chain complexity in lean production
por: Rossetti, Christian L., et al.
Publicado: (2023)

Metformin Protects Skeletal Muscle from Cardiotoxin Induced Degeneration
por: Langone, Francesca, et al.
Publicado: (2014)

Leanness
Publicado: (1892)

Cannot write session to /tmp/vufind_sessions/sess_mof0lehfi3bnuhk23fluncqmib