Enhanced Sensitivity of Nonsmall Cell Lung Cancer with Acquired Resistance to Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors to Phenformin: The Roles of a Metabolic Shift to Oxidative Phosphorylation and Redox Balance

BACKGROUND: Although the efficacy of epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR- TKI) therapy has been proven in non-small cell lung cancer (NSCLC) patients, acquired resistance to EGFR-TKIs presents a serious clinical problem. Hence, the identification of new therapeutic strat...

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Detalles Bibliográficos
Autores principales: Kim, Suntae, Im, Ji Hye, Kim, Wan Kyu, Choi, Young Jae, Lee, Ji-Yoon, Kim, Sang Kyum, Kim, Sun Jo, Kwon, Sung Won, Kang, Keon Wook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342158/
https://www.ncbi.nlm.nih.gov/pubmed/34367462
http://dx.doi.org/10.1155/2021/5428364

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342158/
https://www.ncbi.nlm.nih.gov/pubmed/34367462
http://dx.doi.org/10.1155/2021/5428364

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