Context-dependent modulation of aggressiveness of pediatric tumors by individual oncogenic RAS isoforms

A prototypic pediatric cancer that frequently shows activation of RAS signaling is embryonal rhabdomyosarcoma (ERMS). ERMS also show aberrant Hedgehog (HH)/GLI signaling activity and can be driven by germline mutations in this pathway. We show, that in ERMS cell lines derived from sporadic tumors i....

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Detalles Bibliográficos
Autores principales: Bauer, Julia, Cuvelier, Nicole, Ragab, Nada, Simon-Keller, Katja, Nitzki, Frauke, Geyer, Natalie, Botermann, Dominik S., Elmer, Dominik P., Rosenberger, Albert, Rando, Thomas A., Biressi, Stefano, Fagin, James A., Saur, Dieter, Dullin, Christian, Schildhaus, Hans-Ulrich, Schulz-Schaeffer, Walter, Aberger, Fritz, Uhmann, Anja, Hahn, Heidi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342309/
https://www.ncbi.nlm.nih.gov/pubmed/34172934
http://dx.doi.org/10.1038/s41388-021-01904-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342309/
https://www.ncbi.nlm.nih.gov/pubmed/34172934
http://dx.doi.org/10.1038/s41388-021-01904-4

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