Context-dependent modulation of aggressiveness of pediatric tumors by individual oncogenic RAS isoforms

A prototypic pediatric cancer that frequently shows activation of RAS signaling is embryonal rhabdomyosarcoma (ERMS). ERMS also show aberrant Hedgehog (HH)/GLI signaling activity and can be driven by germline mutations in this pathway. We show, that in ERMS cell lines derived from sporadic tumors i....

Descripción completa

Detalles Bibliográficos
Autores principales: Bauer, Julia, Cuvelier, Nicole, Ragab, Nada, Simon-Keller, Katja, Nitzki, Frauke, Geyer, Natalie, Botermann, Dominik S., Elmer, Dominik P., Rosenberger, Albert, Rando, Thomas A., Biressi, Stefano, Fagin, James A., Saur, Dieter, Dullin, Christian, Schildhaus, Hans-Ulrich, Schulz-Schaeffer, Walter, Aberger, Fritz, Uhmann, Anja, Hahn, Heidi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342309/
https://www.ncbi.nlm.nih.gov/pubmed/34172934
http://dx.doi.org/10.1038/s41388-021-01904-4

Ejemplares similares

Ejemplares similares