Innovative dual system approach for selective eradication of cancer cells using viral-based delivery of natural bacterial toxin–antitoxin system

The inactivation of p53, a tumor suppressor, and the activation of the RAS oncogene are the most frequent genetic alterations in cancer. We have shown that a unique E. coli MazF-MazE toxin–antitoxin (TA) system can be used for selective and effective eradication of RAS-mutated cancer cells. This out...

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Detalles Bibliográficos
Autores principales: Shapira, Shiran, Boustanai, Ilana, Kazanov, Dina, Ben Shimon, Marina, Fokra, Ahmad, Arber, Nadir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342310/
https://www.ncbi.nlm.nih.gov/pubmed/34172933
http://dx.doi.org/10.1038/s41388-021-01792-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342310/
https://www.ncbi.nlm.nih.gov/pubmed/34172933
http://dx.doi.org/10.1038/s41388-021-01792-8

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