Predicting blood-to-plasma concentration ratios of drugs from chemical structures and volumes of distribution in humans

ABSTRACT: Despite their importance in determining the dosing regimen of drugs in the clinic, only a few studies have investigated methods for predicting blood-to-plasma concentration ratios (Rb). This study established an Rb prediction model incorporating typical human pharmacokinetics (PK) paramete...

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Detalles Bibliográficos
Autores principales: Mamada, Hideaki, Iwamoto, Kazuhiko, Nomura, Yukihiro, Uesawa, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342319/
https://www.ncbi.nlm.nih.gov/pubmed/33569705
http://dx.doi.org/10.1007/s11030-021-10186-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342319/
https://www.ncbi.nlm.nih.gov/pubmed/33569705
http://dx.doi.org/10.1007/s11030-021-10186-7

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