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Predicting blood-to-plasma concentration ratios of drugs from chemical structures and volumes of distribution in humans
ABSTRACT: Despite their importance in determining the dosing regimen of drugs in the clinic, only a few studies have investigated methods for predicting blood-to-plasma concentration ratios (Rb). This study established an Rb prediction model incorporating typical human pharmacokinetics (PK) paramete...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342319/ https://www.ncbi.nlm.nih.gov/pubmed/33569705 http://dx.doi.org/10.1007/s11030-021-10186-7 |