Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design

G protein-coupled receptors (GPCRs) are the most common proteins targeted by approved drugs. A complete mechanistic elucidation of large-scale conformational transitions underlying the activation mechanisms of GPCRs is of critical importance for therapeutic drug development. Here, we apply a combine...

Descripción completa

Detalles Bibliográficos
Autores principales: Lu, Shaoyong, He, Xinheng, Yang, Zhao, Chai, Zongtao, Zhou, Shuhua, Wang, Junyan, Rehman, Ashfaq Ur, Ni, Duan, Pu, Jun, Sun, Jinpeng, Zhang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342441/
https://www.ncbi.nlm.nih.gov/pubmed/34354057
http://dx.doi.org/10.1038/s41467-021-25020-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342441/
https://www.ncbi.nlm.nih.gov/pubmed/34354057
http://dx.doi.org/10.1038/s41467-021-25020-9

Ejemplares similares