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Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design

G protein-coupled receptors (GPCRs) are the most common proteins targeted by approved drugs. A complete mechanistic elucidation of large-scale conformational transitions underlying the activation mechanisms of GPCRs is of critical importance for therapeutic drug development. Here, we apply a combine...

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Detalles Bibliográficos
Autores principales:	Lu, Shaoyong, He, Xinheng, Yang, Zhao, Chai, Zongtao, Zhou, Shuhua, Wang, Junyan, Rehman, Ashfaq Ur, Ni, Duan, Pu, Jun, Sun, Jinpeng, Zhang, Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342441/ https://www.ncbi.nlm.nih.gov/pubmed/34354057 http://dx.doi.org/10.1038/s41467-021-25020-9

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