The middle lipin domain adopts a membrane-binding dimeric protein fold

Phospholipid synthesis and fat storage as triglycerides are regulated by lipin phosphatidic acid phosphatases (PAPs), whose enzymatic PAP function requires association with cellular membranes. Using hydrogen deuterium exchange mass spectrometry, we find mouse lipin 1 binds membranes through an N-ter...

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Detalles Bibliográficos
Autores principales: Gu, Weijing, Gao, Shujuan, Wang, Huan, Fleming, Kaelin D., Hoffmann, Reece M., Yang, Jong Won, Patel, Nimi M., Choi, Yong Mi, Burke, John E., Reue, Karen, Airola, Michael V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342540/
https://www.ncbi.nlm.nih.gov/pubmed/34354069
http://dx.doi.org/10.1038/s41467-021-24929-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342540/
https://www.ncbi.nlm.nih.gov/pubmed/34354069
http://dx.doi.org/10.1038/s41467-021-24929-5

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