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The middle lipin domain adopts a membrane-binding dimeric protein fold
Phospholipid synthesis and fat storage as triglycerides are regulated by lipin phosphatidic acid phosphatases (PAPs), whose enzymatic PAP function requires association with cellular membranes. Using hydrogen deuterium exchange mass spectrometry, we find mouse lipin 1 binds membranes through an N-ter...
Autores principales: | Gu, Weijing, Gao, Shujuan, Wang, Huan, Fleming, Kaelin D., Hoffmann, Reece M., Yang, Jong Won, Patel, Nimi M., Choi, Yong Mi, Burke, John E., Reue, Karen, Airola, Michael V. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342540/ https://www.ncbi.nlm.nih.gov/pubmed/34354069 http://dx.doi.org/10.1038/s41467-021-24929-5 |
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