Cargando…

Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment

The tumor microenvironment (TME) is a complex amalgam of tumor cells, immune cells, endothelial cells and fibroblastic stromal cells (FSC). Cancer-associated fibroblasts are generally seen as tumor-promoting entity. However, it is conceivable that particular FSC populations within the TME contribute...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ring, Sandra S., Cupovic, Jovana, Onder, Lucas, Lütge, Mechthild, Perez-Shibayama, Christian, Gil-Cruz, Cristina, Scandella, Elke, De Martin, Angelina, Mörbe, Urs, Hartmann, Fabienne, Wenger, Robert, Spiegl, Matthias, Besse, Andrej, Bonilla, Weldy V., Stemeseder, Felix, Schmidt, Sarah, Orlinger, Klaus K., Krebs, Philippe, Ludewig, Burkhard, Flatz, Lukas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342618/ https://www.ncbi.nlm.nih.gov/pubmed/34354077 http://dx.doi.org/10.1038/s41467-021-25057-w

Ejemplares similares

Adenovirus vector vaccination reprograms pulmonary fibroblastic niches to support protective inflating memory CD8(+) T cells
por: Cupovic, Jovana, et al.
Publicado: (2021)

Intestinal fibroblastic reticular cell niches control innate lymphoid cell homeostasis and function
por: Cheng, Hung-Wei, et al.
Publicado: (2022)

Fibroblastic reticular cell lineage convergence in Peyer’s patches governs intestinal immunity
por: Prados, Alejandro, et al.
Publicado: (2021)

Remodeling of light and dark zone follicular dendritic cells governs germinal center responses
por: Pikor, Natalia B, et al.
Publicado: (2020)

Topological Small-World Organization of the Fibroblastic Reticular Cell Network Determines Lymph Node Functionality
por: Novkovic, Mario, et al.
Publicado: (2016)

Maturation of Lymph Node Fibroblastic Reticular Cells from Myofibroblastic Precursors Is Critical for Antiviral Immunity
por: Chai, Qian, et al.
Publicado: (2013)

Differentiation and activation of fibroblastic reticular cells
por: Lütge, Mechthild, et al.
Publicado: (2021)

Central Nervous System Stromal Cells Control Local CD8(+) T Cell Responses during Virus-Induced Neuroinflammation
por: Cupovic, Jovana, et al.
Publicado: (2016)

Distinct microbial communities colonize tonsillar squamous cell carcinoma
por: De Martin, Angelina, et al.
Publicado: (2021)

Asymmetry of Cell Division in CFSE-Based Lymphocyte Proliferation Analysis
por: Bocharov, Gennady, et al.
Publicado: (2013)

Fibroblastic reticular cells regulate intestinal inflammation via IL-15-mediated control of group 1 ILCs
por: Gil-Cruz, Cristina, et al.
Publicado: (2016)

Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp
por: Cheng, Hung-Wei, et al.
Publicado: (2019)

Conserved stromal–immune cell circuits secure B cell homeostasis and function
por: Lütge, Mechthild, et al.
Publicado: (2023)

PI16(+) reticular cells in human palatine tonsils govern T cell activity in distinct subepithelial niches
por: De Martin, Angelina, et al.
Publicado: (2023)

Thromboxane A2 acts as tonic immunoregulator by preferential disruption of low-avidity CD4(+) T cell–dendritic cell interactions
por: Moalli, Federica, et al.
Publicado: (2014)

B cell homeostasis and follicle confines are governed by fibroblastic reticular cells
por: Cremasco, Viviana, et al.
Publicado: (2014)

Endothelial cell–specific lymphotoxin-β receptor signaling is critical for lymph node and high endothelial venule formation
por: Onder, Lucas, et al.
Publicado: (2013)

A Novel Bacterial Artificial Chromosome-Transgenic Podoplanin–Cre Mouse Targets Lymphoid Organ Stromal Cells in vivo
por: Onder, Lucas, et al.
Publicado: (2011)

Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis
por: Brenig, Robert, et al.
Publicado: (2019)

Heterologous Prime Boost Vaccination Induces Protective Melanoma-Specific CD8(+) T Cell Responses
por: Ring, Sandra S., et al.
Publicado: (2020)

Live-attenuated lymphocytic choriomeningitis virus-based vaccines for active immunotherapy of HPV16-positive cancer
por: Schmidt, Sarah, et al.
Publicado: (2020)

Interleukin 7-expressing fibroblasts promote breast cancer growth through sustenance of tumor cell stemness
por: Boesch, Maximilian, et al.
Publicado: (2018)

Fibroblastic reticular cells at the nexus of innate and adaptive immune responses
por: Perez‐Shibayama, Christian, et al.
Publicado: (2019)

Immunopathological Basis of Virus-induced Myocarditis
por: Maier, Reinhard, et al.
Publicado: (2004)

Visualization and functional characterization of lymphoid organ fibroblasts
por: Onder, Lucas, et al.
Publicado: (2021)

Tight control – decision-making during T cell–vascular endothelial cell interaction
por: Firner, Sonja, et al.
Publicado: (2012)

B cell zone reticular cell microenvironments shape CXCL13 gradient formation
por: Cosgrove, Jason, et al.
Publicado: (2020)

Low Tumor-to-Stroma Ratio Reflects Protective Role of Stroma against Prostate Cancer Progression
por: Nastały, Paulina, et al.
Publicado: (2021)

Integrative Computational Modeling of the Lymph Node Stromal Cell Landscape
por: Novkovic, Mario, et al.
Publicado: (2018)

Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage
por: Bhattacharya, Anannya, et al.
Publicado: (2015)

Protective fibroblastic niches in secondary lymphoid organs
por: De Martin, Angelina, et al.
Publicado: (2023)

RED CELL STROMA IN DOGS : STROMA PROTEIN AND STROMA LIPIDES VARY IN DIFFERENT TYPES OF ANEMIA
por: Robscheit-Robbins, F. S., et al.
Publicado: (1955)

The NFκB-inducing kinase is essential for the developmental programming of skin-resident and IL-17-producing γδ T cells
por: Mair, Florian, et al.
Publicado: (2015)

Molecular Characterization of Virus-induced Autoantibody Responses
por: Ludewig, Burkhard, et al.
Publicado: (2004)

Divergent memory responses driven by adenoviral vectors are impacted by epitope competition
por: Colston, Julia M, et al.
Publicado: (2019)

Dendritic Cell-Specific Delivery of Flt3L by Coronavirus Vectors Secures Induction of Therapeutic Antitumor Immunity
por: Perez-Shibayama, Christian, et al.
Publicado: (2013)

Micronodular Thymoma with Lymphoid Stroma: A Mediastinal Mass Masquerading as a Pericardial Mass
por: Swimley, Kent, et al.
Publicado: (2021)

Type I interferon induces CXCL13 to support ectopic germinal center formation
por: Denton, Alice E., et al.
Publicado: (2019)

Development and Characterization of a Novel Non-Lytic Cancer Immunotherapy Using a Recombinant Arenavirus Vector Platform
por: Lauterbach, Henning, et al.
Publicado: (2021)

Antibodies as biomarker candidates for response and survival to checkpoint inhibitors in melanoma patients
por: Fässler, Mirjam, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_vh5okcjo6dri7jul88ohjofq74