Gemcitabine and APG-1252, a novel small molecule inhibitor of BCL-2/BCL-XL, display a synergistic antitumor effect in nasopharyngeal carcinoma through the JAK-2/STAT3/MCL-1 signaling pathway

Advanced nasopharyngeal carcinoma (NPC) has a poor prognosis, with an unfavorable response to palliative chemotherapy. Unfortunately, there are few effective therapeutic regimens. Therefore, we require novel treatment strategies with enhanced efficacy. The present study aimed to investigate the anti...

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Detalles Bibliográficos
Autores principales: Luo, Fan, Lu, Fei-Teng, Qiu, Miao-Zhen, Zhou, Ting, Ma, Wen-Juan, Luo, Min, Zeng, Kang-Mei, Luo, Qiu-Yun, Pan, Wen-Tao, Zhang, Lin, Xia, Zeng-Fei, Zhang, Zhong-Han, Cao, Jia-Xin, Zhao, Hong-Yun, Zhang, Li, Yang, Da-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342713/
https://www.ncbi.nlm.nih.gov/pubmed/34354046
http://dx.doi.org/10.1038/s41419-021-04042-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342713/
https://www.ncbi.nlm.nih.gov/pubmed/34354046
http://dx.doi.org/10.1038/s41419-021-04042-7

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