Metformin Suppresses the Progress of Diabetes-Accelerated Atherosclerosis by Inhibition of Vascular Smooth Muscle Cell Migration Through AMPK–Pdlim5 Pathway

Backgrounds: Our previous work revealed that AMP-activated protein kinase (AMPK) activation inhibits vascular smooth muscle cell migration in vitro by phosphorylating PDZ and LIM domain 5 (Pdlim5). As metformin is an AMPK activator, we used a mouse vascular smooth muscle cell (VSMC) line and a Myh11...

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Detalles Bibliográficos
Autores principales: Yan, Yi, Li, Ting, Li, Zhonghao, He, Mingyuan, Wang, Dejiang, Xu, Yingyi, Yang, Xuewen, Bai, Yuanyuan, Lao, Yi, Zhang, Zhiyong, Wu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342753/
https://www.ncbi.nlm.nih.gov/pubmed/34368251
http://dx.doi.org/10.3389/fcvm.2021.690627

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342753/
https://www.ncbi.nlm.nih.gov/pubmed/34368251
http://dx.doi.org/10.3389/fcvm.2021.690627

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