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Structural insights into a flavin-dependent dehalogenase HadA explain catalysis and substrate inhibition via quadruple π-stacking
HadA is a flavin-dependent monooxygenase catalyzing hydroxylation plus dehalogenation/denitration, which is useful for biodetoxification and biodetection. In this study, the X-ray structure of wild-type HadA (HadA(WT)) co-complexed with reduced FAD (FADH(–)) and 4-nitrophenol (4NP) (HadA(WT)−FADH(–)...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342789/ https://www.ncbi.nlm.nih.gov/pubmed/34252455 http://dx.doi.org/10.1016/j.jbc.2021.100952 |