Structural insights into a flavin-dependent dehalogenase HadA explain catalysis and substrate inhibition via quadruple π-stacking

HadA is a flavin-dependent monooxygenase catalyzing hydroxylation plus dehalogenation/denitration, which is useful for biodetoxification and biodetection. In this study, the X-ray structure of wild-type HadA (HadA(WT)) co-complexed with reduced FAD (FADH(–)) and 4-nitrophenol (4NP) (HadA(WT)−FADH(–)...

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Detalles Bibliográficos
Autores principales: Pimviriyakul, Panu, Jaruwat, Aritsara, Chitnumsub, Penchit, Chaiyen, Pimchai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342789/
https://www.ncbi.nlm.nih.gov/pubmed/34252455
http://dx.doi.org/10.1016/j.jbc.2021.100952

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