Conformational transitions of caspase-6 in substrate-induced activation process explored by perturbation-response scanning combined with targeted molecular dynamics

Caspase-6 participates in a series of neurodegenerative pathways, and has aroused widespread attentions as a promising molecular target for the treatment of neurodegeneration. Caspase-6 is a homodimer with 6 central-stranded β-sheets and 5 α-helices in each monomer. Previous crystallographic studies...

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Detalles Bibliográficos
Autores principales: Huang, Shuheng, Mei, Hu, Lu, Laichun, Kuang, Zuyin, Heng, Yu, Xu, Lei, Liang, Xiaoqi, Qiu, Minyao, Pan, Xianchao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342898/
https://www.ncbi.nlm.nih.gov/pubmed/34527189
http://dx.doi.org/10.1016/j.csbj.2021.07.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342898/
https://www.ncbi.nlm.nih.gov/pubmed/34527189
http://dx.doi.org/10.1016/j.csbj.2021.07.017

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