Pharmacological Targeting of BMP6-SMAD Mediated Hepcidin Expression Does Not Improve the Outcome of Systemic Infections With Intra-Or Extracellular Gram-Negative Bacteria in Mice

INTRODUCTION: Hepcidin is the systemic master regulator of iron metabolism as it degrades the cellular iron exporter ferroportin. In bacterial infections, hepcidin is upregulated to limit circulating iron for pathogens, thereby increasing iron retention in macrophages. This mechanism withholds iron...

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Detalles Bibliográficos
Autores principales: Hoffmann, Alexander, de Souza, Lara Valente, Seifert, Markus, von Raffay, Laura, Haschka, David, Grubwieser, Philipp, Grander, Manuel, Mitterstiller, Anna-Maria, Nairz, Manfred, Poli, Maura, Weiss, Günter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342937/
https://www.ncbi.nlm.nih.gov/pubmed/34368018
http://dx.doi.org/10.3389/fcimb.2021.705087

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342937/
https://www.ncbi.nlm.nih.gov/pubmed/34368018
http://dx.doi.org/10.3389/fcimb.2021.705087

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