Mechanistic Modeling of a Novel Oncolytic Virus, V937, to Describe Viral Kinetic and Dynamic Processes Following Intratumoral and Intravenous Administration

V937 is an investigational novel oncolytic non-genetically modified Kuykendall strain of Coxsackievirus A21 which is in clinical development for the treatment of advanced solid tumor malignancies. V937 infects and lyses tumor cells expressing the intercellular adhesion molecule I (ICAM-I) receptor....

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Detalles Bibliográficos
Autores principales: Parra-Guillen, Zinnia P., Freshwater, Tomoko, Cao, Youfang, Mayawala, Kapil, Zalba, Sara, Garrido, Maria J., de Alwis, Dinesh, Troconiz, Iñaki F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343024/
https://www.ncbi.nlm.nih.gov/pubmed/34366859
http://dx.doi.org/10.3389/fphar.2021.705443

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343024/
https://www.ncbi.nlm.nih.gov/pubmed/34366859
http://dx.doi.org/10.3389/fphar.2021.705443

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