Tweaking Progranulin Expression: Therapeutic Avenues and Opportunities

Frontotemporal dementia (FTD) is a neurodegenerative disease, leading to behavioral changes and language difficulties. Heterozygous loss-of-function mutations in progranulin (GRN) induce haploinsufficiency of the protein and are associated with up to one-third of all genetic FTD cases worldwide. Whi...

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Detalles Bibliográficos
Autores principales: Terryn, Joke, Verfaillie, Catherine M., Van Damme, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343103/
https://www.ncbi.nlm.nih.gov/pubmed/34366786
http://dx.doi.org/10.3389/fnmol.2021.713031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343103/
https://www.ncbi.nlm.nih.gov/pubmed/34366786
http://dx.doi.org/10.3389/fnmol.2021.713031

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