Targeted inhibition of GRK2 kinase domain by CP-25 to reverse fibroblast-like synoviocytes dysfunction and improve collagen-induced arthritis in rats

Rheumatoid arthritis (RA) is an autoimmune disease and is mainly characterized by abnormal proliferation of fibroblast-like synoviocytes (FLS). The up-regulated cellular membrane expression of G protein coupled receptor kinase 2 (GRK2) of FLS plays a critical role in RA progression, the increase of...

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Detalles Bibliográficos
Autores principales: Han, Chenchen, Li, Yifan, Zhang, Yuwen, Wang, Yang, Cui, Dongqian, Luo, Tingting, Zhang, Yu, Liu, Qian, Li, Hao, Wang, Chun, Xu, Dexiang, Ma, Yang, Wei, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343125/
https://www.ncbi.nlm.nih.gov/pubmed/34386323
http://dx.doi.org/10.1016/j.apsb.2021.01.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343125/
https://www.ncbi.nlm.nih.gov/pubmed/34386323
http://dx.doi.org/10.1016/j.apsb.2021.01.015

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