Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo

Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly due to the inhibitor specificity, toxicity, and d...

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Detalles Bibliográficos
Autores principales: Wu, Xu, Yin, Chun, Ma, Jiang, Chai, Stella, Zhang, Chunyuan, Yao, Sheng, Kadioglu, Onat, Efferth, Thomas, Ye, Yang, To, Kenneth Kin-Wah, Lin, Ge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343194/
https://www.ncbi.nlm.nih.gov/pubmed/34386326
http://dx.doi.org/10.1016/j.apsb.2020.12.021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343194/
https://www.ncbi.nlm.nih.gov/pubmed/34386326
http://dx.doi.org/10.1016/j.apsb.2020.12.021

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