Mechanisms of Impaired Lung Development and Ciliation in Mannosidase-1-Alpha-2 (Man1a2) Mutants

BACKGROUND: Ciliary defects cause heterogenous phenotypes related to mutation burden which lead to impaired development. A previously reported homozygous deletion in the Man1a2 gene causes lethal respiratory failure in newborn pups and decreased lung ciliation compared with wild type (WT) pups. The...

Descripción completa

Detalles Bibliográficos
Autores principales: Ningappa, Mylarappa, Adenuga, Morayooluwa, Ngo, Kim A., Mohamed, Nada, Narayanan, Tejaswini, Prasadan, Krishna, Ashokkumar, Chethan, Das, Jishnu, Schmitt, Lori, Hartman, Hannah, Sehrawat, Anuradha, Salgado, Claudia M., Reyes-Mugica, Miguel, Gittes, George K., Lo, Cecilia W., Subramaniam, Shankar, Sindhi, Rakesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343402/
https://www.ncbi.nlm.nih.gov/pubmed/34366878
http://dx.doi.org/10.3389/fphys.2021.658518

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343402/
https://www.ncbi.nlm.nih.gov/pubmed/34366878
http://dx.doi.org/10.3389/fphys.2021.658518

Ejemplares similares