Mechanisms of Impaired Lung Development and Ciliation in Mannosidase-1-Alpha-2 (Man1a2) Mutants

BACKGROUND: Ciliary defects cause heterogenous phenotypes related to mutation burden which lead to impaired development. A previously reported homozygous deletion in the Man1a2 gene causes lethal respiratory failure in newborn pups and decreased lung ciliation compared with wild type (WT) pups. The...

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Detalles Bibliográficos
Autores principales: Ningappa, Mylarappa, Adenuga, Morayooluwa, Ngo, Kim A., Mohamed, Nada, Narayanan, Tejaswini, Prasadan, Krishna, Ashokkumar, Chethan, Das, Jishnu, Schmitt, Lori, Hartman, Hannah, Sehrawat, Anuradha, Salgado, Claudia M., Reyes-Mugica, Miguel, Gittes, George K., Lo, Cecilia W., Subramaniam, Shankar, Sindhi, Rakesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343402/
https://www.ncbi.nlm.nih.gov/pubmed/34366878
http://dx.doi.org/10.3389/fphys.2021.658518

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