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Aminophylline modulates the permeability of endothelial cells via the Slit2-Robo4 pathway in lipopolysaccharide-induced inflammation

Sepsis and septic shock are the main cause of mortality in intensive care units. The prevention and treatment of sepsis remains a significant challenge worldwide. The endothelial cell barrier plays a critical role in the development of sepsis. Aminophylline, a non-selective phosphodiesterase inhibit...

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Detalles Bibliográficos
Autores principales: Chen, Qin, Zhou, Xiaoming, Hou, Ruonan, Zhou, Zhiliang, Wang, Zhiyi, Chen, Ying, Weng, Jie, Xu, Junnan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343459/
https://www.ncbi.nlm.nih.gov/pubmed/34373728
http://dx.doi.org/10.3892/etm.2021.10474