Ligase 1 is a predictor of platinum resistance and its blockade is synthetically lethal in XRCC1 deficient epithelial ovarian cancers

Rationale: The human ligases (LIG1, LIG3 and LIG4) are essential for the maintenance of genomic integrity by catalysing the formation of phosphodiester bonds between adjacent 5′-phosphoryl and 3′-hydroxyl termini at single and double strand breaks in duplex DNA molecules generated either directly by...

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Detalles Bibliográficos
Autores principales: Ali, Reem, Alabdullah, Muslim, Algethami, Mashael, Alblihy, Adel, Miligy, Islam, Shoqafi, Ahmed, Mesquita, Katia A., Abdel-Fatah, Tarek, Chan, Stephen YT, Chiang, Pei Wen, Mongan, Nigel P, Rakha, Emad A, Tomkinson, Alan E, Madhusudan, Srinivasan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8344016/
https://www.ncbi.nlm.nih.gov/pubmed/34373746
http://dx.doi.org/10.7150/thno.51456

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8344016/
https://www.ncbi.nlm.nih.gov/pubmed/34373746
http://dx.doi.org/10.7150/thno.51456

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