Cargando…

Ligase 1 is a predictor of platinum resistance and its blockade is synthetically lethal in XRCC1 deficient epithelial ovarian cancers

Rationale: The human ligases (LIG1, LIG3 and LIG4) are essential for the maintenance of genomic integrity by catalysing the formation of phosphodiester bonds between adjacent 5′-phosphoryl and 3′-hydroxyl termini at single and double strand breaks in duplex DNA molecules generated either directly by...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ali, Reem, Alabdullah, Muslim, Algethami, Mashael, Alblihy, Adel, Miligy, Islam, Shoqafi, Ahmed, Mesquita, Katia A., Abdel-Fatah, Tarek, Chan, Stephen YT, Chiang, Pei Wen, Mongan, Nigel P, Rakha, Emad A, Tomkinson, Alan E, Madhusudan, Srinivasan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8344016/ https://www.ncbi.nlm.nih.gov/pubmed/34373746 http://dx.doi.org/10.7150/thno.51456

Ejemplares similares

Molecular disruption of DNA polymerase β for platinum sensitisation and synthetic lethality in epithelial ovarian cancers
por: Ali, Reem, et al.
Publicado: (2021)

Targeting Mre11 overcomes platinum resistance and induces synthetic lethality in XRCC1 deficient epithelial ovarian cancers
por: Alblihy, Adel, et al.
Publicado: (2022)

Clinicopathological and Functional Evaluation Reveal NBS1 as a Predictor of Platinum Resistance in Epithelial Ovarian Cancers
por: Alblihy, Adel, et al.
Publicado: (2021)

RAD50 deficiency is a predictor of platinum sensitivity in sporadic epithelial ovarian cancers
por: Alblihy, Adel, et al.
Publicado: (2020)

ATM Regulated PTEN Degradation Is XIAP E3 Ubiquitin Ligase Mediated in p85α Deficient Cancer Cells and Influence Platinum Sensitivity
por: Ali, Reem, et al.
Publicado: (2019)

XRCC1 deficient triple negative breast cancers are sensitive to ATR, ATM and Wee1 inhibitor either alone or in combination with olaparib
por: Ali, Reem, et al.
Publicado: (2020)

FEN1 Blockade for Platinum Chemo-Sensitization and Synthetic Lethality in Epithelial Ovarian Cancers
por: Mesquita, Katia A., et al.
Publicado: (2021)

Unravelling the clinicopathological and functional significance of replication protein A (RPA) heterotrimeric complex in breast cancers
por: Algethami, Mashael, et al.
Publicado: (2023)

Untangling the clinicopathological significance of MRE11-RAD50-NBS1 complex in sporadic breast cancers
por: Alblihy, Adel, et al.
Publicado: (2021)

Selective Killing of BRCA2-Deficient Ovarian Cancer Cells via MRE11 Blockade
por: Alblihy, Adel, et al.
Publicado: (2023)

Evolving DNA repair synthetic lethality targets in cancer
por: Kulkarni, Sanat, et al.
Publicado: (2022)

Towards Personalized Management of Ovarian Cancer
por: Algethami, Mashael, et al.
Publicado: (2022)

Translocation of XRCC1 and DNA ligase IIIα from centrosomes to chromosomes in response to DNA damage in mitotic human cells
por: Okano, Satoshi, et al.
Publicado: (2005)

Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase Inhibition Is Synthetically Lethal in XRCC1 Deficient Ovarian Cancer Cells
por: Sultana, Rebeka, et al.
Publicado: (2013)

ERCC1 Is a Predictor of Anthracycline Resistance and Taxane Sensitivity in Early Stage or Locally Advanced Breast Cancers
por: Abdel-Fatah, Tarek M. A., et al.
Publicado: (2019)

The frequency and clinical significance of DNA polymerase beta (POLβ) expression in breast ductal carcinoma in situ (DCIS)
por: Al-Kawaz, Abdulbaqi, et al.
Publicado: (2021)

Crucial roles for DNA ligase III in mitochondria but not in XRCC1-dependent repair
por: Simsek, Deniz, et al.
Publicado: (2011)

An atypical BRCT–BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase IIIα within a flexible DNA repair complex
por: Hammel, Michal, et al.
Publicado: (2020)

An Intrinsically Disordered APLF Links Ku, DNA-PKcs, and XRCC4-DNA Ligase IV in an Extended Flexible Non-homologous End Joining Complex
por: Hammel, Michal, et al.
Publicado: (2016)

The prognostic significance of Flap Endonuclease 1 (FEN1) in breast ductal carcinoma in situ
por: Al-Kawaz, Abdulbaqi, et al.
Publicado: (2021)

Structure-Based Virtual Ligand Screening on the XRCC4/DNA Ligase IV Interface
por: Menchon, Grégory, et al.
Publicado: (2016)

Platinum-Resistant Ovarian Cancer Is Vulnerable to the cJUN-XRCC4 Pathway Inhibition
por: Xu, Manman, et al.
Publicado: (2022)

The relationship of CDK18 expression in breast cancer to clinicopathological parameters and therapeutic response
por: Barone, Giancarlo, et al.
Publicado: (2018)

DNA repair prognostic index modelling reveals an essential role for base excision repair in influencing clinical outcomes in ER negative and triple negative breast cancers
por: Abdel-Fatah, Tarek M.A., et al.
Publicado: (2015)

XLF-Cernunnos promotes DNA ligase IV–XRCC4 re-adenylation following ligation
por: Riballo, Enriqueta, et al.
Publicado: (2009)

Elevated MMP9 expression in breast cancer is a predictor of shorter patient survival
por: Joseph, Chitra, et al.
Publicado: (2020)

XRCC1 protects against the lethality of induced oxidative DNA damage in nondividing neural cells
por: Kulkarni, Avanti, et al.
Publicado: (2008)

The structural basis for partitioning of the XRCC1/DNA ligase III-α BRCT-mediated dimer complexes
por: Cuneo, Matthew J., et al.
Publicado: (2011)

DNA Ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair
por: Gao, Yankun, et al.
Publicado: (2011)

Association of XRCC1, XRCC2 and XRCC3 Gene Polymorphism with Esophageal Cancer Risk
por: Kaur, Jagjeet, et al.
Publicado: (2020)

Improving mitotic cell counting accuracy and efficiency using phosphohistone‐H3 (PHH3) antibody counterstained with haematoxylin and eosin as part of breast cancer grading
por: Ibrahim, Asmaa, et al.
Publicado: (2022)

Targeting ataxia telangiectasia-mutated- and Rad3-related kinase (ATR) in PTEN-deficient breast cancers for personalized therapy
por: Al-Subhi, Nouf, et al.
Publicado: (2018)

A Meta-Analysis for Association of XRCC1, XRCC2 and XRCC3 Polymorphisms with Susceptibility to Thyroid Cancer
por: Mandegari, Mohammad, et al.
Publicado: (2021)

The prognostic significance of wild-type isocitrate dehydrogenase 2 (IDH2) in breast cancer
por: Aljohani, Abrar I., et al.
Publicado: (2019)

Loss of DNA ligase IV prevents recognition of DNA by double-strand break repair proteins XRCC4 and XLF
por: Jayaram, Sumithra, et al.
Publicado: (2008)

Requirement for Parp-1 and DNA ligases 1 or 3 but not of Xrcc1 in chromosomal translocation formation by backup end joining
por: Soni, Aashish, et al.
Publicado: (2014)

Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4/ligase IV during chromosomal translocation formation
por: Simsek, Deniz, et al.
Publicado: (2010)

ATM mediates oxidative stress-induced dephosphorylation of DNA ligase IIIα
por: Dong, Zhiwan, et al.
Publicado: (2006)

Clinicopathological Significance of ATM-Chk2 Expression in Sporadic Breast Cancers: a Comprehensive Analysis in Large Cohorts()
por: Abdel-Fatah, Tarek M.A., et al.
Publicado: (2014)

Clinicopathological significance of ataxia telangiectasia-mutated (ATM) kinase and ataxia telangiectasia-mutated and Rad3-related (ATR) kinase in MYC overexpressed breast cancers
por: Savva, Constantinos, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_udr1fammdaaj7qs7gtd7m0568i