Autophagy-Related LC3 Accumulation Interacted Directly With LIR Containing RIPK1 and RIPK3, Stimulating Necroptosis in Hypoxic Cardiomyocytes

The exact relationships and detailed mechanisms between autophagy and necroptosis remain obscure. Here, we demonstrated the link between accumulated autophagosome and necroptosis by intervening with autophagic flux. We first confirmed that the LC3 interacting region (LIR) domain is present in the pr...

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Detalles Bibliográficos
Autores principales: Huang, Yao, Feng, Yanhai, Cui, Lin, Yang, Lei, Zhang, Qiong, Zhang, Junhui, Jiang, Xupin, Zhang, Xingyue, Lv, Yanling, Jia, Jie-Zhi, Zhang, Dong-Xia, Huang, Yue-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8344065/
https://www.ncbi.nlm.nih.gov/pubmed/34368130
http://dx.doi.org/10.3389/fcell.2021.679637

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8344065/
https://www.ncbi.nlm.nih.gov/pubmed/34368130
http://dx.doi.org/10.3389/fcell.2021.679637

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