Anticancer activity and toxicity of new quaternary ammonium geldanamycin derivative salts and their mixtures with potentiators

Geldanamycin (GDM) has been modified by different type neutral/acidic/basic substituents (1–7) and by quinuclidine motif (8), transformed into ammonium salts (9–13) at C(17). These compounds have been characterised by spectroscopic and x-ray methods. Derivative 8 shows better potency than GDM in MCF...

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Detalles Bibliográficos
Autores principales: Skrzypczak, Natalia, Pyta, Krystian, Ruszkowski, Piotr, Mikołajczak, Przemysław, Kucińska, Małgorzata, Murias, Marek, Gdaniec, Maria, Bartl, Franz, Przybylski, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8344233/
https://www.ncbi.nlm.nih.gov/pubmed/34344239
http://dx.doi.org/10.1080/14756366.2021.1960829

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8344233/
https://www.ncbi.nlm.nih.gov/pubmed/34344239
http://dx.doi.org/10.1080/14756366.2021.1960829

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