Identifying requirements for RSK2 specific inhibitors

Identifying isoform-specific inhibitors for closely related kinase family members remains a substantial challenge. The necessity for achieving this specificity is exemplified by the RSK family, downstream effectors of ERK1/2, which have divergent physiological effects. The natural product, SL0101, a...

Descripción completa

Detalles Bibliográficos
Autores principales: Wright, Eric B., Fukuda, Shinji, Li, Mingzong, Li, Yu, O’Doherty, George A., Lannigan, Deborah A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8344253/
https://www.ncbi.nlm.nih.gov/pubmed/34348556
http://dx.doi.org/10.1080/14756366.2021.1957862

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8344253/
https://www.ncbi.nlm.nih.gov/pubmed/34348556
http://dx.doi.org/10.1080/14756366.2021.1957862

Ejemplares similares