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Identifying requirements for RSK2 specific inhibitors

Identifying isoform-specific inhibitors for closely related kinase family members remains a substantial challenge. The necessity for achieving this specificity is exemplified by the RSK family, downstream effectors of ERK1/2, which have divergent physiological effects. The natural product, SL0101, a...

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Detalles Bibliográficos
Autores principales:	Wright, Eric B., Fukuda, Shinji, Li, Mingzong, Li, Yu, O’Doherty, George A., Lannigan, Deborah A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8344253/ https://www.ncbi.nlm.nih.gov/pubmed/34348556 http://dx.doi.org/10.1080/14756366.2021.1957862

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